In 1929, Phillips Secretarial School was founded in Lynchburg, Virginia by the late Marjorie Green Phillips. In 1939, the College was incorporated under the laws of the Commonwealth of Virginia, and in that same year moved to 1000 Church Street. In 1954, Virginia Commercial College, which had been established in 1909, was purchased from Mr. Homer Miller and merged with Phillips Business College.

In that same year, Mr. Miller relocated to North Carolina and purchased Motte's Secretarial School, providing local employers with secretarial, business administration, accounting, and general office graduates. In 1987, Phillips Business College was purchased by Atlantic Coast Colleges, Inc. and relocated to its current location on Memorial Avenue.

In 1998, the stock of Miller-Motte Business College and Atlantic Coast Colleges, Inc. was purchased by Delta Educational Systems, Inc. Phillips Business College then changed its name to Miller-Motte Business College. In 2000, the decision was made to revise the school's name to Miller-Motte Technical College to better reflect the increasingly technical nature of the programs being offered.